Fibroboost

Ecklonia Cava:
Ecklonia cava, called noro-kajime in Japan, is the edible brown seaweed that serves as the source for Seanol-F. E. cava is used commercially as a source of hydrocolloids, such as alginate, and as a soup ingredient in Asia. It is also considered a source of iodine.

The phlorotannins found in E. cava, which include phloroglucinol, triphlorethol-A, eckol, bieckol, dieckol, and phlorofucofuroeckol (PFF), have powerful cytoprotective activity. Triphlorethol-A helps protect cells against radiation-induced oxidative damage by scavenging intracellular ROS. It also increases the activities of cellular antioxidant enzymes, including superoxide dismutase, catalase and glutathione peroxidase. Phloroglucinol and eckol have been shown to scavenge hydrogen peroxide and other ROS, preventing lipid peroxidation. They also increase catalase activity and modulate the extracellular signal-regulated kinase (ERK) pathway. The crude polyphenolic fractions (CphF) of E. cava have shown especially strong antioxidant activity, much higher than that of the preservatives BHA and BHT at the same concentration. They have the capacity to scavenge superoxide anions, hydrogen peroxide and hydroxyl radicals. They may have the strongest antiradical activity among natural substances.

Seanol-F:
Seanol-F is a standardized complex of unique natural molecules from E. cava. Seanol-F contains phlorotannins, polyphenolic compounds not found in terrestrial plants but only in certain brown algal species. Phlorotannin-rich extracts of E. cava show significant antioxidant activities, including DPPH radical scavenging, ferric ion reduction, peroxynitrite scavenging, and inhibition of LDL oxidation. As well as modulating levels of reactive oxygen species (ROS), phlorotannins may modulate levels of PGE2, cytokines and prostaglandins.

Seanol-F supports normal function of the nervous system, and the metabolism. It can increase alpha wave production, an indication of increased relaxation. Human studies also show that it can promote daytime wakefulness, likely due to increased blood flow and oxygenation. Subjects given Seanol-F fell asleep faster, slept longer and reported increased soundness of sleep. They felt it increased their energy levels and improved their general condition.

Seanol’s polyphenols:
Unlike polyphenols derived from land plants, Seanol’s polyphenols are 40% oil-soluble. They can pass the blood-brain barrier, and they have a much longer metabolic half-life than that of the usual hydrophilic polyphenols: up to 12 hours vs. typically 30 minutes. Studied since 1992, in-vitro studies, animal studies, and human trials have consistently shown that Seanol compounds have amazing health promoting promise with no evidence of toxicity.

FibroBoost (Fibronol) Clinical Studies:
Dieckol and PFF have been shown in mouse studies to increase the brain level of acetylcholine by inhibiting acetylcholinesterase, and support neurotransmitter levels, with significant benefit for brain function. An in vitro study in cultured human dermal fibroblasts has shown that E. cava phlorotannins may naturally support inhibition of matrix metalloproteinase (MMP) with no cytotoxic effects. Eckol and dieckol showed strong inhibition of both NF-kappaB and AP-1 reporter activity, which were well correlated with their abilities to inhibit MMP-1 expression.

Human studies show that Seanol-F supports cardiovascular function: it inhibits LDL oxidation more powerfully than the same levels of green tea catechins; it supports the body’s fibrinolysis function; it supports cholesterol within normal levels; and it supports normal production of nitric oxide (NO) in the vascular endothelium, which supports normal blood flow. Other studies offer further evidence that Seanol-F compounds may optimize NO levels.